2024/09/29 by Jun Liu, Geng Yuan, Liu, Jun +15 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Computer Vision and Pattern Recognition (cs.CV) #FOS: Biological sciences #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Machine Learning (cs.LG) #Machine Learning in Bioinformatics #Quantitative Methods (q-bio.QM) #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2409.19583
openalex publication_date 2024/09/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In research findings, co-deletion of the 1p/19q gene is associated with clinical outcomes in low-grade gliomas. The ability to predict 1p19q status is critical for treatment planning and patient follow-up. This study aims to utilize a specially MRI-based convolutional neural network for brain cancer detection. Although public networks such as RestNet and AlexNet can effectively diagnose brain cancers using transfer learning, the model includes quite a few weights that have nothing to do with medical images. As a result, the diagnostic results are unreliable by the transfer learning model. To deal with the problem of trustworthiness, we create the model from the ground up, rather than depending on a pre-trained model. To enable flexibility, we combined convolution stacking with a dropout and full connect operation, it improved performance by reducing overfitting. During model training, we also supplement the given dataset and inject Gaussian noise. We use three--fold cross-validation to train the best selection model. Comparing InceptionV3, VGG16, and MobileNetV2 fine-tuned with pre-trained models, our model produces better results. On an validation set of 125 codeletion vs. 31 not codeletion images, the proposed network achieves 96.37% percent F1-score, 97.46% percent precision, and 96.34% percent recall when classifying 1p/19q codeletion and not codeletion images.