2009/06/01 by Paulo M. Camargo, Vojislav Lekovic, Michael Weinlaender +4 · 67 citations
Biochemistry, Genetics and Molecular Biology · Dentistry · Medicine · #Biology #Cell biology #Cleft Lip and Palate Research #Dental Implant Techniques and Outcomes #Dentistry #Internal medicine #Medicine #Periodontal Regeneration and Treatments #Platelet #Platelet-rich plasma #Reentry #Regeneration (biology) #Regenerative medicine #Stem cell
paper · doi:10.1902/jop.2009.080600
published in Journal of Periodontology 80(6), 915-923 (Wiley)
openalex publication_date 2009/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27
BACKGROUND: The purpose of this study was to evaluate the additional benefits provided by the incorporation of platelet-rich plasma (PRP) into a regenerative protocol consisting of bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) in the treatment of intrabony defects in humans. METHODS: Twenty-three paired intrabony defects were surgically treated using a split-mouth design. Defects were treated with BPBM/GTR/PRP (experimental group) or with BPBM/GTR (control group). The clinical parameters evaluated included changes in probing depth, clinical attachment level, and defect fill as revealed by reentry surgeries at 6 months. RESULTS: Preoperative probing depths, attachment levels, and transoperative bone measurements were similar for the two groups. Post-surgical measurements taken at 6 months revealed that both treatment modalities resulted in a significant decrease in probing depth, gain in clinical attachment, and bone fill of the defects compared to baseline. Postoperative differences observed between the two groups were 0.72 +/- 0.36 mm at buccal sites and 0.90 +/- 0.32 mm at lingual sites for probing depth, 0.82 +/- 0.41 mm at buccal sites and 0.78 +/- 0.38 at lingual sites for gain in clinical attachment, and 0.85 +/- 0.36 mm at buccal sites and 0.94 +/- 0.42 mm at lingual sites for defect fill, all favoring the experimental sites. However, none of the differences were statistically significant. CONCLUSION: Within the limitations related to using a small sample size, PRP did not significantly augment the effects of BPBM and GTR in promoting the clinical resolution of intrabony defects.