Extracellular matrix remodelling: the role of matrix metalloproteinases
2003/07/01 by Ivan Stamenkovic · 1,132 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cell #Cell Adhesion Molecules Research #Cell adhesion #Cell adhesion molecule #Cell biology #Cell migration #Chemokine #Extracellular matrix #Immunology #Inflammation #Integrin #Matrix metalloproteinase #Peptidase Inhibition and Analysis #Protease and Inhibitor Mechanisms #Receptor
paper · pdf · doi:10.1002/path.1400
published in The Journal of Pathology 200(4), 448-464
openalex publication_date 2003/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Abstract
Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that cleave the protein components of the extracellular matrix and thereby play a central role in tissue remodelling. For many years following their discovery, MMPs were believed to function primarily as regulators of ECM composition and to facilitate cell migration simply by removing barriers such as collagen. It is becoming increasingly clear, however, that MMPs are implicated in the functional regulation of a host of non-ECM molecules that include growth factors and their receptors, cytokines and chemokines, adhesion receptors and cell surface proteoglycans, and a variety of enzymes. MMPs therefore play an important role in the control of cellular interactions with and response to their environment in conditions that promote tissue turnover, be they physiological, such as normal development, or pathological, such as inflammation and cancer. This review summarizes some of the recent discoveries that have shed new light on the role of MMPs in physiology and disease.
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