Sodium Iodide-Promoted Construction of Fully Substituted 4-Sulfenyl-5-aminopyrazole Derivatives

2025/05/21 by Ziru Huang, Hao Wu, Hangjin Wu +3
Chemistry · #Sulfur-Based Synthesis Techniques #Synthesis and biological activity #Synthesis and Biological Evaluation

paper · doi:10.1021/acs.joc.5c00667

Abstract

Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction of β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage of C-O and S-S bonds and recombination of C-N and C-S bonds. The methodology features broad substrate scope, mild transition-metal-free conditions, and easy manipulation.

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