2018/07/05 by Yekai Huang, Yanan Li, Jianan Sun +3
Chemistry · #Asymmetric Synthesis and Catalysis #Advanced Synthetic Organic Chemistry #Axial and Atropisomeric Chirality Synthesis
paper · doi:10.1021/acs.joc.8b01057
An efficient enantioselective hetero-Diels-Alder reaction was developed under catalysis of a chiral copper complex. A variety of spiropyrrolidones, which bear a tetra-substituted carbon stereocenter, can be obtained in good yields with excellent enantioselectivities by virtue of this method. Furthermore, a substrate-dependent reaction pathway was proposed on the basis of the isolated intermediates.