Regioselective Cycloaddition of Alkenes with tert-butyl Nitrite: A Cascade Approach to the Formation of Δ2-Isoxazolines

2023/10/24 by Yi Liu, Juan Cao, Mei Zhang +4
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Cascade #Catalysis #Chemistry #Chromatography #Combinatorial chemistry #Cycloaddition #Fluorine in Organic Chemistry #Functional group #Medicinal chemistry #Nitrate #Nitrite #Organic Chemistry Cycloaddition Reactions #Organic chemistry #Reaction conditions #Regioselectivity #Synthesis and Catalytic Reactions

paper · doi:10.1021/acs.joc.3c01815

openalex publication_date 2023/10/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A route for cycloaddition reaction of alkenes and tert -butyl nitrite to synthesize Δ 2 -isoxazolines has been developed. The overall process involves the formation of multiple chemical bonds without the use of a catalyst. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of isoxazolines.

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