Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron

2020/10/21 by Peng Gao, Peng P. Gao, Joseph W. Graham +12 · 2 citations
Neuroscience · #Neural dynamics and brain function #Neurobiology and Insect Physiology Research #Olfactory and Sensory Function Studies

paper · doi:10.1152/jn.00734.2019

Abstract

In cortical pyramidal neurons, we recorded glutamate-mediated dendritic plateau potentials with voltage imaging and created a computer model that recreated experimental measures from dendrite and cell body. Our model made new predictions, which were then tested in experiments. Plateau potentials profoundly change neuronal state: a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to firing triggered by other afferent inputs.

Citations

• Quantitative Assessment of the Distributions of Membrane Conductances Involved in Action Potential Backpropagation Along Basal Dendrites
• Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons

Cited by

• Active dendrites enable robust spiking computations despite timing jitter
• Thalamocortical feedback selectively controls pyramidal neuron excitability

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• Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons
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