IgG Neuropathy: An Immunoelectron Microscopic Study

2005/05/01 by Jean-Michel Vallat, Jean‐Michel Vallat, Laurent Magy +3 · 2 citations
Medicine · Neuroscience · Immunology and Microbiology · #Peripheral Neuropathies and Disorders #Hereditary Neurological Disorders #Toxin Mechanisms and Immunotoxins

paper · pdf · doi:10.1093/jnen/64.5.386

Abstract

There are many potential mechanisms of peripheral nerve impairment by a monoclonal IgG dysglobulinemia. In this study, using electron microscopy, we observed widening of the myelin lamellae comparable to that commonly described in IgM neuropathies with antimyelin-associated glycoprotein activity. Such features have yet to be described in IgG neuropathies. In addition, we observed deposits of a granular material in the interstitial tissue of the nerve. By immunoelectron microscopy, we demonstrated the presence of the IgG in the lesions of myelin and the endoneurial space. A direct link between monoclonal dysglobulinemia (regardless of type) and polyneuropathy should be confirmed by nerve biopsy, because the result may influence treatment.

Cited by

• Nerve biopsy: Current indications and decision tools. [europepmc]
• Neurosurgical Intervention for Nerve and Muscle Biopsies. [europepmc]

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