2021/01/25 by Jason Charles Ray, Jason C. Ray, Mahima Kapoor +8 · 21 citations
Medicine · Neuroscience · #Migraine and Headache Studies #Trigeminal Neuralgia and Treatments #Neuropeptides and Animal Physiology
paper · pdf · doi:10.1136/jnnp-2020-324674
Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.