Oxidative stress and neurodegeneration: where are we now?
2006/06/01 by Barry Halliwell · 2,599 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Alzheimer's disease research and treatments #Antioxidant #Biochemistry #Bioinformatics #Biology #Cell biology #Central nervous system #Disease #Immunology #Inflammation #Medicine #Mitochondrial Function and Pathology #Mitochondrion #Neurodegeneration #Neurological diseases and metabolism #Neuroscience #Oxidative damage #Oxidative phosphorylation #Oxidative stress #Pathology #Reactive oxygen species
paper · doi:10.1111/j.1471-4159.2006.03907.x
published in Journal of Neurochemistry 97(6), 1634-1658 (Wiley)
openalex publication_date 2006/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Abstract
The brain and nervous system are prone to oxidative stress, and are inadequately equipped with antioxidant defense systems to prevent 'ongoing' oxidative damage, let alone the extra oxidative damage imposed by the neurodegenerative diseases. Indeed, increased oxidative damage, mitochondrial dysfunction, accumulation of oxidized aggregated proteins, inflammation, and defects in protein clearance constitute complex intertwined pathologies that conspire to kill neurons. After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases.
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