The Origins and Functions of De Novo Genes: Against All Odds?
2022/04/22 by Caroline M. Weisman · 38 citations
Biochemistry, Genetics and Molecular Biology · #Genomics and Phylogenetic Studies #RNA and protein synthesis mechanisms #RNA modifications and cancer
paper · pdf · doi:10.1007/s00239-022-10055-3
Abstract
"De novo" genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.
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- Sequence, Structure, and Functional Space of Drosophila De Novo Proteins. [europepmc]
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- Gene and Genome Duplication in Spiders. [europepmc]
- Oncogenic roles of young human de novo genes and their potential as neoantigens in cancer immunotherapy. [europepmc]
- DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. [europepmc]
- Emergence of antiphage functions from random sequence libraries reveals mechanisms of gene birth. [europepmc]
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- Orphan and de novo Genes in Fungi and Animals: Identification, Origins and Functions. [europepmc]
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- Emergence and Tandem Repeat-Mediated Elongation of a Translated De Novo Open Reading Frame in Human Oncogenic RNA Gene VPS9D1-AS1 (MYU). [europepmc]
- Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals. [europepmc]
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