Defective membrane interactions of familial Parkinson’s disease mutant A30P α-synuclein 1 1Edited by I. B. Holland

2002/01/01 by Euijung Jo, Nola Fuller, R.Peter Rand +5 · 26 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Parkinson's Disease Mechanisms and Treatments #Biotin and Related Studies #Neurological disorders and treatments

paper · doi:10.1006/jmbi.2001.5269

Cited by

• The Lipid-binding Domain of Wild Type and Mutant α-Synuclein
• Yeast cells provide insight into alpha-synuclein biology and pathobiology. [europepmc]
• Lipid rafts mediate the synaptic localization of alpha-synuclein. [europepmc]
• Alpha-synuclein overexpression increases cytosolic catecholamine concentration. [europepmc]
• Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. [europepmc]
• Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. [europepmc]
• Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. [europepmc]
• The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast. [europepmc]
• Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. [europepmc]
• Biophysics of α-synuclein membrane interactions. [europepmc]
• Interaction of α-synuclein with vesicles that mimic mitochondrial membranes. [europepmc]
• The function of α-synuclein. [europepmc]
• Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). [europepmc]
• Cell Biology and Pathophysiology of α-Synuclein. [europepmc]
• Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein? [europepmc]
• The Close Encounter Between Alpha-Synuclein and Mitochondria. [europepmc]
• Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy. [europepmc]
• Membrane binding, internalization, and sorting of alpha-synuclein in the cell. [europepmc]
• Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. [europepmc]
• Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications. [europepmc]
• Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles. [europepmc]
• Protein Quality Control and Lipid Droplet Metabolism. [europepmc]
• The Role of α-Synuclein Oligomers in Parkinson's Disease. [europepmc]
• Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies. [europepmc]
• Structural and Functional Insights into α-Synuclein Fibril Polymorphism. [europepmc]
• Lipid droplet biogenesis and functions in health and disease. [europepmc]