The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex

2008/07/23 by Zhenqiang Li, Martin Kienetz, Maia M. Cherney +3 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Bone Metabolism and Diseases #Cell Adhesion Molecules Research #Protease and Inhibitor Mechanisms

paper · doi:10.1016/j.jmb.2008.07.038

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• Cathepsin K inhibitors for osteoporosis and potential off-target effects. [europepmc]
• Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis? [europepmc]
• Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011. [europepmc]
• Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses. [europepmc]
• Cysteine cathepsins: from structure, function and regulation to new frontiers. [europepmc]
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• Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation. [europepmc]
• Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. [europepmc]
• The role of basic amino acid surface clusters on the collagenase activity of cathepsin K. [europepmc]
• Heparinoids activate a protease, secreted by mucosa and tumors, via tethering supplemented by allostery. [europepmc]
• Structural basis of collagen fiber degradation by cathepsin K. [europepmc]
• Cysteine cathepsin activity regulation by glycosaminoglycans. [europepmc]
• Sulfation and cation effects on the conformational properties of the glycan backbone of chondroitin sulfate disaccharides. [europepmc]
• Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes. [europepmc]
• Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets. [europepmc]
• Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7. [europepmc]
• Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases. [europepmc]
• Cysteinyl cathepsins in cardiovascular diseases. [europepmc]
• Efficient Construction of Atomic-Resolution Models of Non-Sulfated Chondroitin Glycosaminoglycan Using Molecular Dynamics Data. [europepmc]
• Constructing 3-Dimensional Atomic-Resolution Models of Nonsulfated Glycosaminoglycans with Arbitrary Lengths Using Conformations from Molecular Dynamics. [europepmc]
• The Influences of Sulphation, Salt Type, and Salt Concentration on the Structural Heterogeneity of Glycosaminoglycans. [europepmc]
• Identification of Diosmin and Flavin Adenine Dinucleotide as Repurposing Treatments for Monkeypox Virus: A Computational Study. [europepmc]
• Structure determinants defining the specificity of papain-like cysteine proteases. [europepmc]
• Recent applications of computational methods to allosteric drug discovery. [europepmc]
• Heparan sulfate selectively inhibits the collagenase activity of cathepsin K. [europepmc]