Dynamic Structural Rearrangements Between DNA Binding Modes of E. coli SSB Protein

2007/04/25 by Rahul Roy, Alexander G. Kozlov, Timothy M. Lohman +1 · 26 citations
Biochemistry, Genetics and Molecular Biology · #DNA and Nucleic Acid Chemistry #DNA Repair Mechanisms #RNA and protein synthesis mechanisms

paper · doi:10.1016/j.jmb.2007.03.079

Cited by

• Diverse single-stranded nucleic acid binding proteins enable both stable protection and rapid exchange required for biological function
• Transcription initiation in a single-subunit RNA polymerase proceeds through DNA scrunching and rotation of the N-terminal subdomains. [europepmc]
• SSB as an organizer/mobilizer of genome maintenance complexes. [europepmc]
• Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins. [europepmc]
• SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. [europepmc]
• Chaperoning of a replicative polymerase onto a newly assembled DNA-bound sliding clamp by the clamp loader. [europepmc]
• Binding specificity of Escherichia coli single-stranded DNA binding protein for the chi subunit of DNA pol III holoenzyme and PriA helicase. [europepmc]
• Biophysical characterization of DNA binding from single molecule force measurements. [europepmc]
• SSB functions as a sliding platform that migrates on DNA via reptation. [europepmc]
• Specificity of binding of single-stranded DNA-binding protein to its target. [europepmc]
• Single-molecule views of protein movement on single-stranded DNA. [europepmc]
• SSB-DNA binding monitored by fluorescence intensity and anisotropy. [europepmc]
• Multiple C-terminal tails within a single E. coli SSB homotetramer coordinate DNA replication and repair. [europepmc]
• Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transfer. [europepmc]
• Intrinsically disordered C-terminal tails of E. coli single-stranded DNA binding protein regulate cooperative binding to single-stranded DNA. [europepmc]
• A proposal: Evolution of PCNA's role as a marker of newly replicated DNA. [europepmc]
• Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways. [europepmc]
• Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function. [europepmc]
• Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo. [europepmc]
• Glutamate promotes SSB protein-protein Interactions via intrinsically disordered regions. [europepmc]
• Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes. [europepmc]
• Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins. [europepmc]
• ssDNA diffuses along replication protein A via a reptation mechanism. [europepmc]
• Multiprotein E. coli SSB-ssDNA complex shows both stable binding and rapid dissociation due to interprotein interactions. [europepmc]
• The mechanism of action of the SSB interactome reveals it is the first OB-fold family of genome guardians in prokaryotes. [europepmc]
• How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein. [europepmc]