Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux

2018/08/23 by Xiaoqian Wu, Yuyan Qin, Xiaoyan Zhu +7 · 17 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #Cardiac Fibrosis and Remodeling #Cell death mechanisms and regulation

paper · doi:10.1016/j.yjmcc.2018.08.018

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• Endophilin A2 attenuates cardiac hypertrophy induced by isoproterenol through the activation of autophagy. [europepmc]
• miR-199a-5p Represses Protective Autophagy and Overcomes Chemoresistance by Directly Targeting DRAM1 in Acute Myeloid Leukemia. [europepmc]
• The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes. [europepmc]
• SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity. [europepmc]
• The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells. [europepmc]
• Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. [europepmc]
• Ozone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HPS70) expression through activating the JAK2/STAT3 Pathway. [europepmc]
• Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats. [europepmc]
• Adenosine A2a Receptor Regulates Autophagy Flux and Apoptosis to Alleviate Ischemia-Reperfusion Injury via the cAMP/PKA Signaling Pathway. [europepmc]
• Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation. [europepmc]
• Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum . [europepmc]
• A review on regulation of DNA methylation during post-myocardial infarction. [europepmc]
• Naked Gene Delivery Induces Autophagy for Effective Treatment of Acute Lung Injury in a Mouse Model. [europepmc]
• Assembly of ceria-Nrf2 nanoparticles as macrophage-targeting ROS scavengers protects against myocardial infarction. [europepmc]
• DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism. [europepmc]
• DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation. [europepmc]
• Aging-rewired metabolic cues promote autophagy and senescence via DRAM1. [europepmc]