Familial atypical multiple mole-melanoma syndrome.

1978/10/01 by H T Lynch, Henry T. Lynch, B C Frichot +2 · 16 citations
Medicine · #Parasitic Diseases Research and Treatment #Dermatological diseases and infestations #Cutaneous Melanoma Detection and Management

paper · pdf · doi:10.1136/jmg.15.5.352

Abstract

A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.

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