2024/06/11 by Mohsen Haghighat, Haghighat, Mohsen, Thomas E. Darcie +3
Biochemistry, Genetics and Molecular Biology · Engineering · #Advanced Biosensing Techniques and Applications #Applied Physics (physics.app-ph) #FOS: Physical sciences #Microfluidic and Capillary Electrophoresis Applications #Photonic and Optical Devices
paper · pdf · doi:10.48550/arxiv.2406.07701
openalex publication_date 2024/06/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
This paper demonstrates an on-chip anhydrous D-glucose sensor based using a coplanar stripline (CPS) on a thin (1 um) silicon nitride membrane at terahertz (THz) frequencies. A thin layer (~10 um) of D-glucose was placed in close proximity to the CPS and the transmission response was measured using a modified THz-TDS setup. The D-glucose introduces frequency-dependent changes to the effective permittivity of the CPS resulting in a modified spectral response at the receiver. Measurement results show absorption signatures at 1.42 THz and 2.07 THz corresponding to the first two significant resonances beyond 1 THz for D-glucose allowing for label-free detection. The frequency-dependent attenuation coefficient was estimated by simulation for several D-glucose layer thicknesses using a modified Lorentz model. Measurement results align with simulations and other literature that use free-space THz radiation. This work verifies on-chip THz sensing of D-glucose and presents a pathway towards on-chip sensing of other materials at THz frequencies.