2000/10/01 by Alicia Sanchez‐Mazas, Q.‐G. Steiner, Christophe Grundschober +1 · 43 citations
Immunology and Microbiology · Medicine · #T-cell and B-cell Immunology #Immune Cell Function and Interaction #Monoclonal and Polyclonal Antibodies Research #Linkage disequilibrium #Allele frequency #Allele #Haplotype #Population #Biology #Genetics #Human leukocyte antigen #Demography #Gene #Antigen
paper · pdf · doi:10.1034/j.1399-0039.2000.560402.x
published in Tissue Antigens 56(4), 303-312 (Wiley)
openalex publication_date 2000/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
HLA-Cw alleles were determined by high-resolution polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) oligotyping in a sample of 165 Mandenka, a population from Eastern Senegal previously analysed for A/B and DRB/DQB polymorphisms. A total of 18 Cw alleles were identified, with Cw*0401/5 and 1601 accounting for a combined frequency of 36%. A comparison of Cw allele frequencies among several populations of different origins, Mandenka, Swiss, English, Ashkenazi Jews from the UK and Japanese, reveals a high genetic heterogeneity among them, but also a much closer relationship between Mandenka, Europeans and Ashkenazi than between any of these populations and Japanese. Cw*0501, Cw*0701 and Cw*1601, among others, appear to be restricted to the European and African populations. Many B-Cw haplotypes exhibit a significant linkage disequilibrium in the Mandenka, among which B*3501-Cw*0401 and B*7801-Cw*1601, formed by the most frequent B and Cw alleles, and B*5201-Cw*1601, B*5702-Cw*18 and B*4410-Cw*0401, not yet observed in other populations. B*3501-Cw*0401 is found with similar frequencies in Europeans. The results possibly support a close historical relationship between Africans and Europeans as compared to East Asiatics. However, the HLA-Cw frequency distributions are characterised by an excess of heterozygotes, indicating that balancing selection may have played a role in the evolution of this polymorphism.