Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

2019/01/04 by Stephen S. Dominy, Casey Lynch, Florian Ermini +23 · 1 voice · 1,891 citations
Medicine · Dentistry · Health Professions · Neuroscience · #Alzheimer's disease research and treatments #Oral microbiology and periodontitis research #Oral and gingival health research #Porphyromonas gingivalis #Disease #Alzheimer's disease #Causation #Medicine #Biology #Neuroscience #Pathology #Internal medicine #Periodontitis #Philosophy

paper · pdf · doi:10.1126/sciadv.aau3333

published in Science Advances 5(1), eaau3333 (American Association for the Advancement of Science)

openalex publication_date 2019/01/04 · openalex created_date 2019/02/21 · openalex updated_date 2026/08/08

Abstract

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.

Citations

• Bacterial proteinases as targets for the development of second-generation antibiotics
• Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
• An African origin for the intimate association between humans and Helicobacter pylori
• THE UBIQUITIN SYSTEM

Cited by

• The many roads to dementia: a systems view of Alzheimer's disease
• Identification of gingipains in glioblastoma tumors and evidence that P. gingivalis infection drives IL-6 and PD-L1 expression in glioma cells

Discussions

• Dementia is a metabolic disease - MD Chaffee [lemmy, 3 points, 2 comments]