2024/07/06 by Weronika Andrzejewska, Nadzeya Khinevich, Andrzejewska, Weronika +13
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Biosensing Techniques and Applications #Advanced biosensing and bioanalysis techniques #FOS: Physical sciences #Materials Science (cond-mat.mtrl-sci) #Monoclonal and Polyclonal Antibodies Research #Optics (physics.optics)
paper · pdf · doi:10.48550/arxiv.2407.05037
openalex publication_date 2024/07/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Plasmonic surface lattice resonance (SLR) is a phenomenon in which individual localized surface plasmon resonances (LSPRs) excited in periodically-arranged plasmonic nanoparticles couple through the interaction with propagating diffracted incident light. The SLR optical absorption peak is by at least one order of magnitude more intense than the LSPR one, making SLR superior for applications in which LSPR is commonly used. Recently, we have developed a route for the fabrication of spherical virus-like particles (VLPs) with plasmonic cores and protein coronas, where the LSPR in the cores amplifies vibrational signals originating from protein-antibody bonding, showing the potential of VLPs in biodetection. However, the signals were not strong enough to detect antibodies at very low concentrations. Here, we show that by ordering the VLPs in periodic nanoarrays exhibiting SLR amplifies the signals by two orders of magnitude, revealing superior potential of SLR arrays in ultrasensitive biodetection.