Diet-derived galactose reprograms hepatocytes to prevent T cell exhaustion and elicit antitumour immunity

2025/08/01 by Xian Du, Wenyan Li, Guiying Li +18 · 1 voice · 3 citations
Immunology and Microbiology · Medicine · Biochemistry, Genetics and Molecular Biology · #Immune Cell Function and Interaction #Growth Hormone and Insulin-like Growth Factors #Cancer, Hypoxia, and Metabolism

paper · doi:10.1038/s41556-025-01716-8

Cited by

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Discussions

• Feeding mice galactose rewires hepatocyte metabolism to boost CD8+ T cell function via IGFBP-1, relieving exhaustion, thus suppressing tumors. Neat diet-immunity link with an interesting mechanism @na [bsky, 15 points, 0 comments]