Enhancers: five essential questions

2013/03/18 by Len A. Pennacchio, L Pennacchio, Wendy Bickmore +5 · 533 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Social Sciences · #Animal Genetics and Reproduction #Autism Spectrum Disorder Research #Biology #Child Development and Digital Technology #Computational biology #Enhancer #Evolutionary biology #Gene #Genetics #Transcription factor

paper · open access · doi:10.1038/nrg3458

published in Nature Reviews Genetics 14(4), 288-295 (Springer Science and Business Media LLC)

crossref issued 2013/03/18 · crossref published 2013/03/18 · crossref published-online 2013/03/18 · openalex publication_date 2013/03/18 · crossref created 2013/03/18 · crossref published-print 2013/04/01 · crossref deposited 2023/05/19 · openalex created_date 2025/10/10 · crossref indexed 2026/08/07 · openalex updated_date 2026/08/08

Citations

• Histone H3K27ac separates active from poised enhancers and predicts developmental state
• The lac Repressor Displays Facilitated Diffusion in Living Cells
• Ultraconserved Elements in the Human Genome
• Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
• Long Noncoding RNAs with Enhancer-like Function in Human Cells
• A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly
• Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
• Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
• Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
• An integrated encyclopedia of DNA elements in the human genome

Cited by

• Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions
• Epigenomics [wikipedia]