2007/05/22 by Christopher Lau, Katherine Anitole, Colette S. Hodes +3 · 2,585 citations
Environmental Science · Earth and Planetary Sciences · Chemistry · #Per- and polyfluoroalkyl substances research #Toxic Organic Pollutants Impact #Atmospheric chemistry and aerosols #Perfluorooctanoic acid #Wildlife #Perfluorooctane #Chemistry #Biology #Environmental chemistry #Ecology
paper · doi:10.1093/toxsci/kfm128
published in Toxicological Sciences 99(2), 366-394 (Oxford University Press)
openalex publication_date 2007/05/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
In recent years, human and wildlife monitoring studies have identified perfluoroalkyl acids (PFAA) worldwide. This has led to efforts to better understand the hazards that may be inherent in these compounds, as well as the global distribution of the PFAAs. Much attention has focused on understanding the toxicology of the two most widely known PFAAs, perfluorooctanoic acid, and perfluorooctane sulfate. More recently, research was extended to other PFAAs. There has been substantial progress in understanding additional aspects of the toxicology of these compounds, particularly related to the developmental toxicity, immunotoxicity, hepatotoxicity, and the potential modes of action. This review provides an overview of the recent advances in the toxicology and mode of action for PFAAs, and of the monitoring data now available for the environment, wildlife, and humans. Several avenues of research are proposed that would further our understanding of this class of compounds.