2006/07/06 by Holger Römpler, Nadin Rohland, Carles Lalueza‐Fox +6 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Nursing · #Allele #Biochemical Analysis and Sensing Techniques #Biology #Coat #Ecology #Evolutionary biology #Gene #Genetics #Meat and Animal Product Quality #Melanocortin 1 receptor #Polymorphism (computer science) #melanin and skin pigmentation
paper · doi:10.1126/science.1128994
openalex publication_date 2006/07/06 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/23
By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species. We found two alleles and show that one allele produces a functional protein whereas the other one encodes a protein with strongly reduced activity. This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring.