2004/01/01 by Min Su Kim, Seong Mok Jeong, Jae‐Hak Park +2 · 27 citations
Medicine · Veterinary · #Anesthesia and Sedative Agents #Veterinary Pharmacology and Anesthesia #Antibiotics Pharmacokinetics and Efficacy #Atipamezole #Medetomidine #Ketamine #Anesthesia #Medicine #Heart rate #Anesthetic #Glycopyrrolate #Respiratory rate #Blood pressure #Internal medicine #Atropine
paper · pdf · doi:10.1538/expanim.53.423
published in EXPERIMENTAL ANIMALS 53(5), 423-428
openalex publication_date 2004/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/08
This study was performed to determine the optimal reversal dosage of atipamezole on medetomidine-ketamine combination anesthesia. The subject rabbits were divided into five groups (n=5/group), and all were anesthetized with intravenous medetomidine (0.35 mg/kg) and ketamine (5 mg/kg). Atipamezole was administered intravenously 35 min after administration of the medetomidine-ketamine mixture, at doses of a quarter, a half, equal, or two times higher than the preceding medetomidine -ketamine dose according to experimental group. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured every five minutes and the mean arousal time (MAT) was also recorded. This study revealed that the optimal atipamezole dosage to achieve reversal effects is equal to or double the dose of medetomidine. At these dosages, HR and MAP significantly recovered and MAT was significantly shortened with no side effects being observed (p<0.05).