2026/06/19 by Sam P. B. van Beljouw, Yuping Li · 1 voice
Environmental Science · Medicine · Biochemistry, Genetics and Molecular Biology · #Bacteriophages and microbial interactions #Monoclonal and Polyclonal Antibodies Research #Genomics and Phylogenetic Studies
paper · pdf · doi:10.1038/s41467-026-74333-0
Jumbo bacteriophages are bacterial viruses with double-stranded DNA genomes exceeding 200 kb. These viral giants feature exceptionally large virions, expansive genetic repertoires, and in some cases, remarkable eukaryotic-like traits. Jumbo phages challenge long-standing notions of phage simplicity, redefining the boundaries of what a phage can be. In this Review, we examine the biology of jumbo bacteriophages, highlighting their diversity, evolutionary origins, distinctive morphologies and lifecycles, complex interactions with bacterial hosts, and their potential for biotechnology and therapy, with a focus on, but not limited to, the Chimalliviridae phages.