Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

2004/07/01 by Zeev Pancer, Chris T. Amemiya, Götz R. A. Ehrhardt +3 · 1 voice · 42 citations
Immunology and Microbiology · #Aquaculture disease management and microbiota #Immune Cell Function and Interaction #Immune Response and Inflammation

paper · doi:10.1038/nature02740

Cited by

• A lamprey neural cell type atlas illuminates the origins of the vertebrate brain
• Human genetic basis of interindividual variability in the course of infection
• Evolution of adaptive immunity: Implications of a third lymphocyte lineage in lampreys
• Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells
• Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future
• Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis
• The origins of vertebrate adaptive immunity
• Evolution of isotype switching
• Origin and evolution of the adaptive immune system: genetic events and selective pressures
• Evidence for sponges as sister to all other animals from partitioned phylogenomics with mixture models and recoding
• THE EVOLUTION OF ADAPTIVE IMMUNITY
• GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
• Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
• Reconstructing immune phylogeny: new perspectives
• Reshaping Antibody Diversity
• A thymus candidate in lampreys
• The Evolution of Adaptive Immune Systems
• Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey. [europepmc]
• Innate and adaptive immunity: specificities and signaling hierarchies revisited. [europepmc]
• Reconstructing immune phylogeny: new perspectives. [europepmc]
• Comparative and developmental study of the immune system in Xenopus. [europepmc]
• A hypervariable invertebrate allodeterminant. [europepmc]
• Dual nature of the adaptive immune system in lampreys. [europepmc]
• Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. [europepmc]
• Origin and evolution of the adaptive immune system: genetic events and selective pressures. [europepmc]
• The role of the immune system in the initiation and persistence of the Euprymna scolopes--Vibrio fischeri symbiosis. [europepmc]
• Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses. [europepmc]
• The origins of vertebrate adaptive immunity. [europepmc]
• Recent findings on the structure and function of teleost IgT. [europepmc]
• VLR-based adaptive immunity. [europepmc]
• Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses. [europepmc]
• Reshaping antibody diversity. [europepmc]
• The genome sequence of the colonial chordate, Botryllus schlosseri. [europepmc]
• The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. [europepmc]
• Chordate evolution and the three-phylum system. [europepmc]
• Fish Immunoglobulins. [europepmc]
• Guidelines for the use of flow cytometry and cell sorting in immunological studies. [europepmc]
• A cold-blooded view of adaptive immunity. [europepmc]
• Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). [europepmc]
• Programmed genome rearrangements in ciliates. [europepmc]
• Anatomy of teleost fish immune structures and organs. [europepmc]
• Evidence for sponges as sister to all other animals from partitioned phylogenomics with mixture models and recoding. [europepmc]

Discussions

• Evolution invented adaptive immunity TWICE. Lampreys have no antibodies, yet Pancer et al. showed they build 10¹⁴+ unique immune receptors using leucine-rich repeats, a completely different molecular [bsky, 15 points, 1 comments]