Human gut M cells resemble dendritic cells and present gluten antigen

2025/12/10 by Daisong Wang, Sangho Lim, Willine J. van de Wetering +19 · 1 voice · 5 citations
Medicine · #Celiac Disease Research and Management #Microscopic Colitis #Gastrointestinal motility and disorders

paper · doi:10.1038/s41586-025-09829-8

Citations

• Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

Cited by

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• Gene-Environment Interactions in Celiac Disease: The Role of the Intestinal Epithelium. [europepmc]
• Gut microbiota-M cell co-culture in inflammatory bowel disease and its therapeutic potential in organoid platforms. [europepmc]
• Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells. [europepmc]

Discussions

• #WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present ant [bsky, 15 points, 0 comments]