2011/10/10 by Mark G. Kortepeter, Daniel G. Bausch, Mike Bray · 329 citations
Medicine · Health Professions · #Viral Infections and Outbreaks Research #Viral Infections and Vectors #Disaster Response and Management #Outbreak #Case fatality rate #Ebola Hemorrhagic Fever #Ebola virus #Medicine #Ebolavirus #Virology #Intensive care medicine #Epidemiology #Pathology
paper · pdf · doi:10.1093/infdis/jir299
published in The Journal of Infectious Diseases 204(suppl_3), S810-S816 (Oxford University Press)
openalex publication_date 2011/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks.