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Persistence of Ebola Virus in Ocular Fluid during Convalescence

2015/05/07 by Jay B. Varkey, Jessica G. Shantha, Ian Crozier +11 · 474 citations
Medicine · Health Professions · #Viral Infections and Outbreaks Research #Disaster Response and Management #Retinal and Optic Conditions #Convalescence #Medicine #Viremia #Ebolavirus #Ebola virus #Uveitis #Incidence (geometry) #Virology #Disease #Virus #Immunology #Internal medicine

paper · pdf · doi:10.1056/nejmoa1500306

published in New England Journal of Medicine 372(25), 2423-2427 (Massachusetts Medical Society)

openalex publication_date 2015/05/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

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