Tuberculosis Drug Resistance: A Global Threat

2003/01/15 by Jean B. Nachega, Richard E. Chaisson · 224 citations
Medicine · #Tuberculosis Research and Epidemiology #Mycobacterium research and diagnosis #Pneumocystis jirovecii pneumonia detection and treatment #Medicine #Tuberculosis #Drug resistance #Multiple drug resistance #Outbreak #Drug #Extensively drug-resistant tuberculosis #Intensive care medicine #Virology #Mycobacterium tuberculosis #Pharmacology #Microbiology #Biology #Pathology

paper · pdf · doi:10.1086/344657

published in Clinical Infectious Diseases 36(Supplement_1), S24-S30 (Oxford University Press)

openalex publication_date 2003/01/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Resistance to antituberculosis drugs has been a problem since the era of chemotherapy began. After dramatic outbreaks of multidrug-resistant tuberculosis (MDR-TB) in the early 1990s, resistance became recognized as a global problem. MDR-TB now threatens the inhabitants of countries in Europe, Asia, Africa, and the Americas. An understanding of the molecular basis of drug resistance may contribute to the development of new drugs. Management of MDR-TB relies on prompt recognition and treatment with at least 3 drugs to which an isolate is susceptible.

Citations

• An Outbreak of Multidrug-Resistant Tuberculosis among Hospitalized Patients with the Acquired Immunodeficiency Syndrome
• The Major Infectious Diseases in the World — To Treat or Not to Treat?
• Treatment of Multidrug-Resistant Tuberculosis
• The Emergence of Drug-Resistant Tuberculosis in New York City
• Streptomycin Treatment of Pulmonary Tuberculosis: A Medical Research Council Investigation

Cited by

• Multidrug-resistant tuberculosis [wikipedia]