2019/07/09 by Andrew H. Moeller, João Carlos Gomes‐Neto, Sara Mantz +5 · 50 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Gut microbiota and health #Diet and metabolism studies #Tryptophan and brain disorders #Adaptation (eye) #Gut flora #Biology #House mice #Zoology #Ecology #Immunology #Neuroscience
paper · doi:10.1128/msphere.00387-19
published in mSphere 4(4) (American Society for Microbiology)
openalex publication_date 2019/07/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
The communities of bacteria that reside within mammalian guts are deeply integrated with their hosts, but the impact of this gut microbiota on mammalian evolution remains poorly understood. Experimental transplantation of the gut microbiota between mouse species revealed that foreign gut microbiotas lowered the host growth rate and upregulated the expression of an immunomodulating cytokine. In addition, foreign gut microbiotas increased host liver sizes and attenuated sex-specific differences in host muscle and fat content. These results suggest that the house mouse has adapted to its species-specific gut microbiota.