2019/05/29 by Kyung Joon Oh, Roberto Romero, Jee Yoon Park +2 · 48 citations
paper · doi:10.1515/jpm-2019-0003
published in Journal of Perinatal Medicine 47(5), 516-527 (Walter de Gruyter GmbH)
crossref issued 2019/05/29 · crossref published 2019/05/29 · crossref published-online 2019/05/29 · crossref created 2019/05/29 · crossref published-print 2019/07/26 · crossref deposited 2024/07/18 · crossref indexed 2026/08/01
Abstract Objectives To determine the relationship between the intensity of the intra-amniotic inflammatory response and the gestational age at the time of diagnosis in cases with preterm premature rupture of membranes (PROM) and intra-amniotic infection caused by Ureaplasma spp. Methods A retrospective cohort study was conducted which included 71 women with preterm PROM and a positive amniotic fluid culture with Ureaplasma spp. Women with mixed intra-amniotic infections were excluded. The study population was classified into three groups according to gestational age: group 1, Results (1) The median values of amniotic fluid MMP-8 concentration and WBC count were the highest in the extreme preterm PROM group and the lowest in the late preterm PROM group (P Conclusion The earlier the gestational age at the time of PROM, the higher the intensity of the intra-amniotic inflammatory response in women with preterm PROM and intra-amniotic infection caused by Ureaplasma spp.