β-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice

2020/09/22 by Felix Zhou, Xiaoyun Wu, Ivan Pinos +5 · 23 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Nursing · #Antioxidant Activity and Oxidative Stress #Retinoids in leukemia and cellular processes #Fatty Acid Research and Health

paper · doi:10.1194/jlr.ra120001066

Abstract

mice despite accumulating β-carotene in plasma and atherosclerotic lesions. We discarded the implication of myeloid BCO1 in the development of atherosclerosis by performing bone marrow transplant experiments. Lipid production assays found that retinoic acid, the active form of vitamin A, reduced the secretion of newly synthetized triglyceride and cholesteryl ester in cell culture and mice. Overall, our findings provide insights into the role of BCO1 activity and vitamin A in atherosclerosis progression through the regulation of hepatic lipid metabolism.

Citations

• AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet

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