2025/01/14 by Busra Isleyen, Semra Acer, Ömer Çelik +5 · 4 citations
Chemistry · Medicine · #Angiogenesis #Bevacizumab #Biochemistry #Chemistry #Chemotherapy #Cornea #Corneal Surgery and Treatments #Corneal neovascularization #Glutathione #Inflammation #Internal medicine #Malondialdehyde #Medicine #Neovascularization #Ocular Surface and Contact Lens #Ophthalmology #Oxidative stress #Pharmacology #Surgery #VEGF receptors #Vascular endothelial growth factor #Wound Healing and Treatments
paper · doi:10.1097/ico.0000000000003804
published in Cornea 44(7), 905-910 (Lippincott Williams & Wilkins)
crossref issued 2025/01/14 · crossref published 2025/01/14 · crossref published-online 2025/01/14 · openalex publication_date 2025/01/14 · crossref created 2025/01/14 · crossref deposited 2025/06/04 · crossref published-print 2025/07/01 · openalex created_date 2025/10/10 · crossref indexed 2026/08/07 · openalex updated_date 2026/08/08
PURPOSE: To evaluate the effect of subconjunctival injection of dexpanthenol on corneal neovascularization and inflammation in rats with induced chemical burns. METHODS: This experimental study included 40 female albino Wistar rats. Chemical burns were induced in the right eye of all rats on the first day, and the left eye was used as a control. Rats were randomly divided into 5 groups. The no-treatment group (group 1) received no injections. Balanced salt solution injection in the sham group (group 2), dexpanthenol injection in the dexpanthenol group (group 3), bevacizumab injection in the bevacizumab group (group 4), and combined dexpanthenol and bevacizumab injection in the combined group (group 5) were administered subconjunctivally on day 7. The right corneas of all rats were photographed on days 7 and 14 to evaluate corneal neovascularization. The 2 corneal images were compared, and the differences were analyzed. All rats were euthanized, and the corneas were isolated. The levels of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A, malondialdehyde (MDA), apoptosis, reduced glutathione (GSH), and total oxidant status were measured in rat corneas. RESULTS: Dexpanthenol reduced corneal neovascularization, and the difference was significant compared with the no-treatment and sham groups ( P < 0.05). No significant difference in corneal neovascularization was observed between the dexpanthenol and bevacizumab groups. Dexpanthenol had a significant positive effect on vascular endothelial growth factor-A, TNF-α, total oxidant status, MDA, and GSH levels compared with the sham group ( P < 0.05). CONCLUSIONS: Dexpanthenol may help control corneal neovascularization and inflammation after chemical burns.