Divergent BRAF Inhibitor Resistance Mechanisms Revealed through Epigenetic Mapping

2022/12/15 by Yuanyuan Kang, Zhenyu Ji, He Li +1 · 6 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Cancer research #Chromatin #Chromatin immunoprecipitation #Computational biology #Enhancer #Epigenetics #Gene #Gene expression #Genetics #Genomics and Chromatin Dynamics #Melanoma #Melanoma and MAPK Pathways #Metastatic melanoma #Promoter #Protein Degradation and Inhibitors #Transcription factor #Transcriptome #Vemurafenib

paper · doi:10.1016/j.jid.2022.03.039

published in Journal of Investigative Dermatology 143(5), 842-853.e6 (Elsevier BV)

openalex publication_date 2022/12/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Citations

• Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor–Resistant Cutaneous Melanomas
• Cancer statistics, 2020

Cited by

• Loss of ten-eleven translocation 2 (TET2) facilitates aggressive behaviour in cutaneous melanoma by inducing peroxisome proliferator-activated receptor-γ coactivator 1α expression and oxidative phosphorylation. [europepmc]
• BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations. [europepmc]