Gamma-Secretase Inhibitors Downregulate the Profibrotic NOTCH Signaling Pathway in Recessive Dystrophic Epidermolysis Bullosa

2024/01/20 by Angelo Giuseppe Condorelli, Rebecca Nobili, A. Muglia +11 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Skin and Cellular Biology Research #Cell Adhesion Molecules Research #Wnt/β-catenin signaling in development and cancer

paper · pdf · doi:10.1016/j.jid.2023.10.045

Citations

• Making sense of latent TGFβ activation
• Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility
• Transforming growth factor–β in tissue fibrosis

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• miR-129-1-3p down-regulation promotes BAG cochaperone 3 (BAG3)-driven pro-fibrotic processes in primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. [europepmc]