Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

2009/02/26 by Jasper G. van den Boorn, Debby Konijnenberg, Trees A. M. Dellemijn +8 · 30 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #melanin and skin pigmentation #T-cell and B-cell Immunology #Atherosclerosis and Cardiovascular Diseases

paper · pdf · doi:10.1038/jid.2009.32

Cited by

• Mechanisms of melanocyte death in vitiligo
• Recent clinical and mechanistic insights into vitiligo offer new treatment options for cell-specific autoimmunity
• Revealing biological mechanisms of skin pigment recovery during treatment in vitiligo patients: A proteomic analysis
• The skin delivery of tofacitinib citrate using transethosomes and hybridized ethosomes/nanostructured lipid carriers for vitiligo therapy: Dermatopharmacokinetics and in vivo assays
• Immune and Biological Changes during Treatment in Patients with Nonsegmental Vitiligo and their Relation to Repigmentation
• A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. [europepmc]
• Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. [europepmc]
• Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. [europepmc]
• Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin. [europepmc]
• Innate immune mechanisms in vitiligo: danger from within. [europepmc]
• A quantitative increase in regulatory T cells controls development of vitiligo. [europepmc]
• CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. [europepmc]
• The role of IL-17 in vitiligo: A review. [europepmc]
• Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity. [europepmc]
• Vitiligo Pathogenesis and Emerging Treatments. [europepmc]
• IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases. [europepmc]
• Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. [europepmc]
• Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo. [europepmc]
• Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity. [europepmc]
• SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. [europepmc]
• The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review. [europepmc]
• The Role of Memory CD8 + T Cells in Vitiligo. [europepmc]
• Targeting the Janus Kinase Family in Autoimmune Skin Diseases. [europepmc]
• Mechanisms of melanocyte death in vitiligo. [europepmc]
• Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. [europepmc]
• Resident Memory T Cells in Autoimmune Skin Diseases. [europepmc]
• Not-so-opposite ends of the spectrum: CD8 + T cell dysfunction across chronic infection, cancer and autoimmunity. [europepmc]
• scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function. [europepmc]
• Janus Kinase Inhibitors in the Treatment of Vitiligo: A Review. [europepmc]
• Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment. [europepmc]