Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D3, and Retinoic Acid

2010/01/21 by Shin Morizane, Kenshi Yamasaki, Filamer D. Kabigting +2 · 25 citations
Immunology and Microbiology · Medicine · Biochemistry, Genetics and Molecular Biology · #Antimicrobial Peptides and Activities #Coagulation, Bradykinin, Polyphosphates, and Angioedema #Transgenic Plants and Applications

paper · doi:10.1038/jid.2009.435

Citations

• Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

Cited by

• TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. [europepmc]
• Expression of epidermal CAMP changes in parallel with permeability barrier status. [europepmc]
• Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands. [europepmc]
• Clinical, cellular, and molecular aspects in the pathophysiology of rosacea. [europepmc]
• Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. [europepmc]
• Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin. [europepmc]
• Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. [europepmc]
• PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. [europepmc]
• Multiple immune-modulatory functions of cathelicidin host defense peptides. [europepmc]
• Commensal bacteria lipoteichoic acid increases skin mast cell antimicrobial activity against vaccinia viruses. [europepmc]
• Sphingolipids and antimicrobial peptides: function and roles in atopic dermatitis. [europepmc]
• Local Burn Injury Promotes Defects in the Epidermal Lipid and Antimicrobial Peptide Barriers in Human Autograft Skin and Burn Margin: Implications for Burn Wound Healing and Graft Survival. [europepmc]
• Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. [europepmc]
• Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models. [europepmc]
• Recent advances in understanding and managing rosacea. [europepmc]
• Retinoids Enhance the Expression of Cathelicidin Antimicrobial Peptide during Reactive Dermal Adipogenesis. [europepmc]
• Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [europepmc]
• Psoriasis and Antimicrobial Peptides. [europepmc]
• The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics. [europepmc]
• Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. [europepmc]
• A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea. [europepmc]
• Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models. [europepmc]
• Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures. [europepmc]
• Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases. [europepmc]
• Innate immunity and microbial dysbiosis in hidradenitis suppurativa - vicious cycle of chronic inflammation. [europepmc]