2008/04/22 by E. Park, Jimmy D. Bell, Andrew Baker +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Social Sciences · #Bioinformatics #Biology #Education and Teacher Training #Grey matter #Heme Oxygenase-1 and Carbon Monoxide #Inclusive Education and Diversity #Intensive care medicine #Intervention (counseling) #Magnetic resonance imaging #Medicine #Political science #Psychiatry #S100 Proteins and Annexins #Social Sciences and Policies #Traumatic Brain Injury and Neurovascular Disturbances #Traumatic brain injury #White matter
paper · pdf · doi:10.1503/cmaj.080282
openalex publication_date 2009/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/04/28
Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention.