2010/10/01 by Jun Maruta, Stephanie W. Lee, Emily F. Jacobs +1 · 1 citation
Medicine · Psychology · Neuroscience · #Traumatic Brain Injury Research #Traumatic Brain Injury and Neurovascular Disturbances #Advanced Neuroimaging Techniques and Applications #Concussion #White matter #Diffusion MRI #Cognition #Traumatic brain injury #Psychology #Neuroscience #Neuroimaging #Magnetic resonance imaging #Tractography #Neurocognitive #Post-concussion syndrome #Physical medicine and rehabilitation #Cognitive psychology #Poison control #Medicine #Injury prevention #Psychiatry #Radiology
paper · pdf · doi:10.1111/j.1749-6632.2010.05695.x
openalex publication_date 2010/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
The etiology, imaging, and behavioral assessment of mild traumatic brain injury (mTBI) are daunting fields, given the lack of a cohesive neurobiological explanation for the observed cognitive deficits seen following mTBI. Although subjective patient self-report is the leading method of diagnosing mTBI, current scientific evidence suggests that quantitative measures of predictive timing, such as visual tracking, could be a useful adjunct to guide the assessment of attention and to screen for advanced brain imaging. Magnetic resonance diffusion tensor imaging (DTI) has demonstrated that mTBI is associated with widespread microstructural changes that include those in the frontal white matter tracts. Deficits observed during predictive visual tracking correlate with DTI findings that show lesions localized in neural pathways subserving the cognitive functions often disrupted in mTBI. Unifying the anatomical and behavioral approaches, the emerging evidence supports an explanation for mTBI that the observed cognitive impairments are a result of predictive timing deficits caused by shearing injuries in the frontal white matter tracts.