Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms

2021/02/01 by Jean Krutmann, Tamara Schikowski, Akimichi Morita +1 · 242 citations
Environmental Science · Medicine · #Air Quality and Health Impacts #Biology #Cell biology #Compartment (ship) #Dermatology #Effects and risks of endocrine disrupting chemicals #Medicine #Skin Aging #Skin Protection and Aging #Skin barrier

paper · doi:10.1016/j.jid.2020.12.011

published in Journal of Investigative Dermatology 141(4), 1096-1103 (Elsevier BV)

openalex publication_date 2021/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

As a barrier organ, the skin is an ideal model to study environmentally-induced (extrinsic) aging. In this review, we explain the development of extrinsic skin aging as a consequence of skin exposure to specific exposomal factors, their interaction with each other, and the modification of their effects on the skin by genetic factors. We also review the evidence that exposure to these exposomal factors causes extrinsic skin aging by mechanisms that critically involve the accumulation of macromolecular damage and the subsequent development of functionally altered and/or senescent fibroblasts in the dermal compartment of the skin.

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