2008/06/18 by Catherine Decaens, C. Decaens, Marjorie Durand +2 · 117 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cell #Cell biology #Cell polarity #Cytoskeleton #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Golgi apparatus #Hepatocyte #In vitro #Liver Disease Diagnosis and Treatment #Pancreatic function and diabetes #Polarity (international relations)
paper · pdf · doi:10.1042/bc20070127
published in Biology of the Cell 100(7), 387-398 (Wiley)
openalex publication_date 2008/06/18 · crossref created 2008/06/18 · crossref issued 2008/07/01 · crossref published 2008/07/01 · crossref published-print 2008/07/01 · crossref published-online 2012/01/09 · openalex created_date 2016/06/24 · crossref deposited 2023/10/11 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/04
The correct functioning of the liver is ensured by the setting and the maintenance of hepatocyte polarity. The complex polarity of the hepatocyte is characterized by the existence of several basolateral and apical poles per cell. Many in vitro models are available for studying hepatocyte polarity, but which are the more suitable? To answer this question, we aimed to identify criteria which determine the typical hepatocyte polarity. Therefore, we compiled a range of protein markers of membrane domains in rat hepatocytes and investigated their involvement in hepatocytic functions. Then, we focused on the relationship between hepatic functions and the cytoskeleton, Golgi apparatus and endoplasmic reticulum. Subsequently, we compared different cell lines expressing hepatocyte polarity. Finally, to demonstrate the usefulness of some of these lines, we presented new data on endoplasmic reticulum organization in relation to polarity.