2014/03/28 by Joice de Faria Poloni, Henrique Chapola, Bruno César Feltes +1 · 20 citations
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Angiogenesis #Biochemistry #Biology #Cancer research #Caveolin-1 and cellular processes #Cell biology #Endocrinology #Lipid microdomain #Membrane #Oxidative stress #Reactive oxygen species #Signal transduction #Sphingolipid #Sphingolipid Metabolism and Signaling
paper · doi:10.1111/boc.201400008
published in Biology of the Cell 106(6), 167-181 (Wiley)
openalex publication_date 2014/03/28 · crossref created 2014/03/28 · crossref issued 2014/04/28 · crossref published 2014/04/28 · crossref published-online 2014/04/28 · crossref published-print 2014/06/01 · crossref deposited 2023/10/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23 · crossref indexed 2026/08/04
The heart is the first organ in the embryo to form. Its structural and functional complexity is the result of a thorough developmental program, where sphingolipids play an important role in cardiogenesis, heart maturation, angiogenesis, the regulation of vascular tone and vessel permeability. Sphingolipids are necessary for signal transduction and membrane microdomain formation. In addition, recent evidence suggests that sphingolipid metabolism is directly interconnected to the modulation of oxidative stress. However, cardiovascular development is highly sensitive to excessive reactive species production, and disturbances in sphingolipid metabolism can lead to abnormal development and cardiac disease. Therefore, in this review, we address the molecular link between sphingolipids and oxidative stress, connecting these pathways to cardiovascular development and cardiovascular disease.