2010/01/01 by Katrin Ottersbach, Elaine Dzierzak
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cell biology #Fetus #Genetics #Haematopoiesis #Immunology #Mesenchymal stem cell research #Placenta #Pregnancy #Pregnancy and preeclampsia studies #Progenitor cell #Stem cell #Zebrafish Biomedical Research Applications
paper · doi:10.1387/ijdb.093057ko
crossref issued 2010/01/01 · crossref published 2010/01/01 · crossref published-print 2010/01/01 · openalex publication_date 2010/01/01 · crossref created 2010/08/16 · crossref deposited 2025/01/10 · openalex created_date 2025/10/10 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/04
The recent description of the placenta as a tissue rich in haematopoietic stem and progenitor cells has not only opened up a whole new line of investigation into how haematopoiesis is regulated in this unique mammalian tissue, but has also resulted in the revisiting of long-standing and yet unanswered questions about the significance of having multiple haematopoietic organs during development. Due to its remarkable capacity for haematopoietic stem/progenitor cell expansion, the study of placental haematopoiesis is also of obvious clinical interest. In the following pages, we summarise what is currently known about the haematopoietic regulatory processes in the murine placenta and describe our most recent data demonstrating that the human placenta, like its murine counterpart, is also a source of haematopoietic stem and progenitor cells throughout development.