2008/01/01 by H.M. Wang, Marc Bodenstein, M. Bodenstein +2
Immunology and Microbiology · Medicine · #ARDS #Acute respiratory distress #Diffuse alveolar damage #Immune Response and Inflammation #Intensive care medicine #Internal medicine #Lung #Medicine #Neonatal Respiratory Health Research #Pathological #Pathology #Respiratory Support and Mechanisms #Respiratory physiology
paper · pdf · doi:10.1159/000121471
crossref issued 2008/01/01 · crossref published 2008/01/01 · crossref published-print 2008/01/01 · openalex publication_date 2008/01/01 · crossref published-online 2008/03/19 · crossref created 2008/03/19 · crossref deposited 2025/04/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15 · crossref indexed 2026/08/06
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute diffuse damage to the pulmonary parenchyma by a variety of local or systemic insults. Increased alveolar capillary membrane permeability was recognized as the common end organ injury and a central feature in all forms of ALI/ARDS. Although great strides have been made in understanding the pathogenesis of ALI/ARDS and in intensive care medicine, the treatment approach to ARDS is still relying on ventilatory and cardiovascular support based on the recognition of the clinical picture. In the course of evaluating novel treatment approaches to ARDS, 3 models of ALI induced in different species, i.e. the surfactant washout lavage model, the oleic acid intravenous injection model and the endotoxin injection model, were widely used. This review gives an overview of the pathological characteristics of these models from studies in pigs, dogs or sheep. We believe that a good morphological description of these models, both spatially and temporally, will help us gain a better understanding of the real pathophysiological picture and apply these models more accurately and liberally in evaluating novel treatment approaches to ARDS.