2017/11/21 by Jingjie Liang, Shaoyu Wang, Zhengguang Wang · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Assisted reproductive technology #Bioinformatics #Biology #Cell biology #Embryo #Endocrinology #Endometriosis Research and Treatment #Endometrium #Gene #Genetics #Infertility #MicroRNA in disease regulation #Pregnancy #Reproductive System and Pregnancy #microRNA
paper · pdf · doi:10.1186/s12958-017-0309-7
openalex publication_date 2017/11/21 · openalex created_date 2017/12/04 · openalex updated_date 2026/07/29
Failure of embryo implantation is a major limiting factor in early pregnancy and assisted reproduction. Determinants of implantation include the embryo viability, the endometrial receptivity, and embryo-maternal interactions. Multiple molecules are involved in the regulation of implantation, but their specific regulatory mechanisms remain unclear. MicroRNA (miRNA), functioning as the transcriptional regulator of gene expression, has been widely reported to be involved in embryo implantation. Recent studies reveal that miRNAs not only act inside the cells, but also can be released by cells into the extracellular environment through multiple packaging forms, facilitating intercellular communication and providing indicative information associated with physiological and pathological conditions. The discovery of extracellular miRNAs shed new light on implantation studies. MiRNAs provide new mechanisms for embryo-maternal communication. Moreover, they may serve as non-invasive biomarkers for embryo selection and assessment of endometrial receptivity in assisted reproduction, which improves the accuracy of evaluation while reducing the mechanical damage to the tissue. In this review, we discuss the involvement of miRNAs in embryo implantation from several aspects, focusing on the role of extracellular miRNAs and their potential applications in assisted reproductive technologies (ART) to promote fertility efficiency.