2020/06/07 by C. Codaccioni, Camille Codaccioni, Olivier Picone +30
Immunology and Microbiology · Medicine · #Amoebic Infections and Treatments #Fetus #Gestational age #Medicine #Obstetrics #Parasitic infections in humans and animals #Pathology #Pediatrics #Pregnancy #Radiology #Seroconversion #Serology #Toxoplasma gondii Research Studies #Toxoplasmosis #Ultrasound
paper · doi:10.1002/pd.5756
openalex publication_date 2020/06/07 · crossref created 2020/06/07 · crossref issued 2020/06/30 · crossref published 2020/06/30 · crossref published-online 2020/06/30 · crossref published-print 2020/12/01 · crossref deposited 2023/08/29 · openalex created_date 2025/10/10 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/04
OBJECTIVE: To describe the lesions detected by prenatal ultrasound examination in congenital toxoplasmosis (CT). METHODS: We retrospectively analyzed all cases of fetal infection with Toxoplasma gondii with ultrasound anomalies described by fetal medicine experts in 2009 to 2019 in 30 French centers. RESULTS: Eighty-eight cases of CT were included. Forty-five (51.1%) had one or more cerebral signs only, 35 (39.8%) had cerebral plus extracerebral signs and 8 (9.1%) had extracerebral signs only. The main cerebral signs were intracranial hyperechogenic nodular foci (n = 60) of which 20 were isolated, ventriculomegalies (n = 44) which generally increased during follow-up, and periventricular abscesses (n = 12). The main extracerebral signs were hepatomegaly and/or splenomegaly (n = 14), small for gestational age (n = 14), ascites (n = 14, including 2 with hydrops), and hyperechogenic bowel (n = 11). Maternal infection occurred mostly in the first or second trimester (81 cases), periconceptionally in one and in the third trimester in six cases. The first ultrasound signs were detected after a median of 7 weeks (range: 1.4; 24.0) following maternal toxoplasmosis seroconversion. CONCLUSION: While no sign was specific of CT, there were typical associations of cerebral signs with or without extracerebral signs. Detailed ultrasound examination could improve prognostic evaluation, as well as diagnosis of CT in settings lacking serological screening.