The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

2021/07/20 by Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B Schwarz +26 · 6 citations
Medicine · #Hepatitis B Virus Studies #Liver Disease Diagnosis and Treatment #Hepatitis C virus research

paper · doi:10.1093/infdis/jiab373

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Cited by

• A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook. [europepmc]
• Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells. [europepmc]
• IL-2 produced by HBV-specific T cells as a biomarker of viral control and predictor of response to PD-1 therapy across clinical phases of chronic hepatitis B. [europepmc]
• Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver. [europepmc]
• Illuminating HBV with multi-scale modeling. [europepmc]
• Combined Analysis of Protein Induced by Prothrombin Induced by Vitamin K Absence (PIVKA) and Alpha-L-Fucosidase (AFU) with Alpha-Fetoprotein (AFP) May Improve the Diagnostic Efficacy for Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis B. [europepmc]

Related

• Levels of Antibodies to Hepatitis B Core Antigen Are Associated With Liver Inflammation and Response to Peginterferon in Patients With Chronic Hepatitis B
• Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage
• Noninvasive Detection of Occult yet Significant Liver Pathology in Alanine Aminotransferase–Normal Chronic Hepatitis B: A Multicenter Study
• Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
• Changes in Liver Fibrosis in Patients with Chronic Hepatitis B Treated with Pegylated Interferon Combined with Oral Antiviral Agents: A 48-Week Observation from a Prospective Cohort Study