The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

2021/07/20 by Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B Schwarz +26 · 13 citations
Medicine · #Cytokine #Hepatitis #Hepatitis B #Hepatitis B Virus Studies #Hepatitis C virus research #Immunology #Inflammation #Liver Disease Diagnosis and Treatment #Medicine #Seroconversion #Virus

paper · open access · doi:10.1093/infdis/jiab373

published in The Journal of Infectious Diseases 225(3), 470-475 (Oxford University Press)

openalex publication_date 2021/07/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

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